尿促性素（HMG）是一種從絕經(jīng)后婦女的尿液中提取的無(wú)菌的糖蛋白促性腺激素。含有尿促卵泡素（FSH）和黃體生成素（LH）。 該物質(zhì)具有刺激女性卵巢卵泡生長(zhǎng)和成熟，維護(hù)和刺激男性睪丸激素產(chǎn)生相關(guān)的睪丸間質(zhì)細(xì)胞，負(fù)責(zé)曲細(xì)精管中精子的成熟和發(fā)展的作用。
該物質(zhì)具有刺激女性卵巢卵泡生長(zhǎng)和成熟，維護(hù)和刺激男性睪丸激素產(chǎn)生相關(guān)的睪丸間質(zhì)細(xì)胞，負(fù)責(zé)曲細(xì)精管中精子的成熟和發(fā)展的作用。用于誘導(dǎo)具有規(guī)則或不規(guī)則的細(xì)胞的無(wú)排卵的女性的排卵。用于刺激具有原發(fā)或繼發(fā)性腺性腺功能低下癥的男性的精子產(chǎn)生。
|
性狀 |
類白色或微黃色粉末 |
|
溶解度 |
可溶于水 |
|
鑒別 |
符合規(guī)定 |
|
FSH活性 |
不少于200 IU-FSH/mg |
|
LH活性 |
不少于200 IU-FSH/mg |
|
FSH:LH |
大約1:1 |
|
水份 |
不超過(guò)5.0% |
|
殘留溶劑 |
0.5% |
|
細(xì)菌內(nèi)毒素 |
不超過(guò)1.0 EU/FSH IU |
|
異常** |
陰性 100 IU/0.5ml/鼠 |
|
人類免疫缺陷病毒I型和II型抗原 |
陰性 |
|
乙肝病毒表面抗原 |
陰性 |
|
丙肝病毒抗體 |
陰性 |
Human Menopausal Gonadotropin (HMG) is a sterile preparation containing glycoprotein gonadotropin extracted from human post-menopausal urine. It contains both Follicle Stimulating Hormone (FSH) and Luteinising Hormone (LH).
The substance has the property in females of stimulating growth and maturation of ovarian follicles and property in males of maintaining and stimulating testicular, interstitial cells related to testosterone production and of being responsible for the full development and maturation of spermatozoa in the seminiferous tubules.
The substance is indicated for the induction of ovulation in the anovulatory woman with regular or irregular cells. For men, it is indicated for the stimulation of spermatogenesis in men who have primary or secondary hypogonadotropic hypogonadism.
Haoran Biopharma can supply bulk HMG with the following specifications. Products of various specifications can also be prepared according to customers' requests.
|
Appearance |
Almost White or slightly yellow powder |
|
Solubility |
Freely soluble |
|
Identification |
Identified |
|
FSH activity |
Not less than 200 IU-FSH/mg |
|
LH activity |
Not less than 200 IU-LH/mg |
|
FSH:LH |
About 1:1 |
|
** |
Not more than 5.0% |
|
Residual Solvent |
0.5% |
|
Bacterial endotoxins |
Not more than 1.0 EU/FSH IU |
|
Abnormal toxicity |
Negative at 100 IU/0.5ml/mouse |
|
HIV I+II antibody |
Negative |
|
Hepatitis B surface antigen |
Negative |
|
HCV antibodies |
Negative |
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