尿激酶（UK）是從人新鮮尿液中提取的一種溶栓劑。它可以激活纖溶酶原為纖溶酶，隨后水解纖維蛋白和溶解血栓。 該產(chǎn)品主要用于治療急性心肌梗死，急性腦血栓，腦血管閉塞，外周動(dòng)靜脈血栓，視網(wǎng)膜中央靜脈血栓和其他由于新血凝塊的形成而引起的梗死性疾病。
浩然生物可以供應(yīng)以下規(guī)格的UK原料。也可以根據(jù)客戶的需求準(zhǔn)備其他規(guī)格的產(chǎn)品。
|
性狀 |
白色或類(lèi)白色無(wú)定形粉末 |
|
鑒別 |
符合規(guī)定 |
|
活性 |
不少于80,000 IU/mg |
|
比活 |
不少于120,000 IU/mg蛋白質(zhì) |
|
溶液澄清度 |
澄清 |
|
凝血質(zhì)樣物質(zhì) |
不少于150 IU/ml |
|
高分子量尿激酶 |
不少于90% |
|
細(xì)菌內(nèi)毒素 |
不超過(guò)1.0 EU /10,000 IU |
|
異常** |
陰性 5000 IU/0.5ml/鼠 |
|
人類(lèi)免疫缺陷病毒I型和II型抗原 |
陰性 |
|
乙肝病毒表面抗原 |
陰性 |
|
丙肝病毒抗體 |
陰性 |
Urokinase (UK) is a thrombolytic agent extracted from human fresh urine. It can activate plasminogen to plasmin, with the subsequent hydrolysis of fibrin and dissolution of thrombi.
This product is mainly used in the treatment of acute myocardial infarction, acute cerebral thrombosis, occlusion of cerebral blood vessel, peripheral arteriovenous thrombi, central retinal arteriovenous thrombi and other infarction diseases due to freshly formed clot
Haoran Biopharma can supply bulk UK with the following specifications. Products of various specifications can also be prepared according to customers' requests.
|
Appearance |
White or almost white, amorphous powder |
|
Identification |
Identified |
|
Activity |
Not less than 80,000 IU/mg |
|
Specific activity |
Not less than 120,000 IU/mg protein |
|
Clarity of solution |
Clear |
|
Thromboplastic contaminants |
Not less than 150 IU/ml |
|
HMW-Urokinase |
Not less than 90% |
|
Bacterial endotoxins |
Not more than 1.0 EU /10,000 IU |
|
Abnormal toxicity |
Negative at 5000 IU/0.5ml/mouse |
|
HIV I+II antibody |
Negative |
|
Hepatitis B surface antigen |
Negative |
|
HCV antibodies |
Negative |
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